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Firazyr (icatibant) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat sudden attacks of hereditary angioedema (HAE) in adults 18 years of age and older.
Firazyr is a bradykinin B2 receptor blocker. It stops a body chemical called bradykinin from attaching to its receptor. Bradykinin can cause swelling, inflammation, and pain. By blocking bradykinin, Firazyr helps treat symptoms during a sudden HAE attack.
Doctors prescribe Firazyr to treat acute HAE attacks in adults age 18 and older.
Firazyr is given as an injection under the skin of the stomach area. After training from a healthcare professional, people may give themselves the injection when they notice symptoms of an HAE attack.
The injection should be given into a fold of skin on the stomach, about 2 to 4 inches below the belly button on either side.
The recommended dose of Firazyr for HAE is 30 milligrams injected under the skin of the stomach area. If symptoms do not improve enough or come back, another 30 milligrams dose may be given at least six hours later.
Do not use more than three doses in 24 hours.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
In clinical studies of Firazyr for HAE, the most common side effects include:
Firazyr can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Takeda Pharmaceuticals U.S.A., the manufacturer of Firazyr, offers the Takeda Patient Support Co-Pay Assistance Program. Eligible people with commercial insurance may have up to 100 percent of their out-of-pocket copay costs covered.
The Takeda Patient Support Co-Pay Assistance Program also offers help with enrollment, insurance navigation, treatment coordination through your specialty pharmacy or site of care, arrangement for in-home injection training, and educational and community support resources.
To learn more, visit the Takeda Patient Support Co-Pay Assistance Program website or call 866-888-0660.
Tell your doctor if you have any allergies to icatibant injection or any ingredients in Firazyr.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Do not take Firazyr if you have had a serious allergic reaction to icatibant injection or any of its ingredients.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Firazyr, talk with your doctor about the risks and benefits.
These answers are fact-checked by our editorial staff.
How effective is Firazyr for HAE?
In one study of adults with sudden HAE attacks, symptoms were reduced by 50 percent in a median of 2 hours with Firazyr. With placebo, the median time was 19.8 hours.
In the same study, almost complete symptom relief took a median of 8 hours with Firazyr and 36 hours with placebo.
Across three studies, the median time to a 50 percent reduction in symptoms ranged from 2 to 2.3 hours. In an extension study of repeated attacks, 93 percent of attacks were treated with one dose.
How long does Firazyr take to work for HAE?
Across three clinical studies, Firazyr reduced symptoms by 50 percent in a median of 2 to 2.3 hours.
In a study where people gave themselves Firazyr, the median time to a 50 percent reduction in symptoms was 2.6 hours.
What should I do if I miss a dose of Firazyr for HAE?
Firazyr is not taken on a regular daily schedule, so there is usually no missed dose.
Use Firazyr when you notice symptoms of an acute HAE attack. If symptoms do not improve enough or come back, another dose may be given at least six hours later. Do not use more than three doses in 24 hours.
On myHAEteam, people share their experiences with HAE, get advice, and find support from others who understand.
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